A Controlled Randomized Trial Assessing Regenerative Therapy in Healing of Chronic Pressure Ulcers

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We are sharing one of the most cited article from our journal. Article entitled “A Controlled Randomized Trial Assessing Regenerative Therapy in Healing of Chronic Pressure Ulcers” was well written by Dr. Mahmoud F. Sakr.

Abstract

Aim: To assess the efficacy and safety of regenerative therapy as compared to wet-to-moist saline dressings in healing of chronic pressure ulcers (CPUs).

Method: Consecutive patients (n=105) with CPUs (n=218) treated at three different hospitals were randomized to receive Moist Exposed Burn Ointment (MEBO) dressings (Regenerative group, n=55 with 115 ulcers) or wet-to-moist saline dressings (Control group, n=50 with 103 ulcers). Data collected prospectively included demographics, clinical, biochemical and ulcer features. Ulcer surface area (SA) and healing index (HI) were calculated and compared at twoweek intervals for 12 weeks.

Results: Sixty-one patients (58.1%) were male and 44 (41.9%) were female. Their mean age was 69.5 years. There was an increase in HI and reduction in SA starting at two and four weeks, respectively in the regenerative group. At 12 weeks, 61.7% (71/115) of ulcers treated with MEBO had complete healing (HI=1) versus 28.2% (29/103) of controls (p=0.000).

Conclusion: In addition to its safety, MEBO significantly promotes the healing of CPUs with significant increase in HI of any given ulcer as early as two weeks of treatment, and significant reduction of ulcer SA starting at four weeks with complete healing of more than 60% of ulcers by 12 weeks.

Here is the link to view complete article: https://www.longdom.org/open-access/a-controlled-randomized-trial-assessing-regenerative-therapy-in-healing-ofchronic-pressure-ulcers.pdf

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